Cell Line Models

Authenticated Human Cancer Cell Line Panel

All cell lines are obtained from ATCC or equivalent recognized repositories and authenticated by STR profiling. Regular mycoplasma testing is performed to ensure culture integrity throughout experimental use.

Authenticated Cell Line Panel

Human Cancer Cell Lines in Active Use

MCF-7

ATCC HTB-22

Breast Adenocarcinoma

Luminal A, ER+/PR+/HER2−

Estrogen receptor-positive, hormone-responsive breast cancer model. Widely used for evaluation of endocrine-targeting and antiproliferative agents. Expresses functional p53.

MDA-MB-231

ATCC HTB-26

Breast Adenocarcinoma

Triple-Negative (TNBC)

Highly aggressive triple-negative breast cancer model lacking ER, PR, and HER2 expression. Representative of the most therapeutically challenging breast cancer subtype. KRAS and BRAF mutant.

HCT116

ATCC CCL-247

Colorectal Carcinoma

Microsatellite Unstable (MSI-H)

Mismatch repair-deficient colorectal cancer model with high microsatellite instability. KRAS G13D mutant. Widely used for evaluation of DNA damage response and apoptosis-inducing agents.

SW480

ATCC CCL-228

Colorectal Carcinoma

Chromosomally Unstable (CIN)

Chromosomally unstable colorectal cancer model derived from a primary tumor. KRAS G12V mutant. Complements HCT116 for evaluation across distinct colorectal mutational backgrounds.

A549

ATCC CCL-185

Non-Small Cell Lung Carcinoma

Lung Adenocarcinoma

KRAS G12S-mutant lung adenocarcinoma model. Widely employed for evaluation of compounds targeting RAS-driven oncogenic signaling and for general NSCLC antiproliferative screening.

HL-60

ATCC CCL-240

Acute Promyelocytic Leukemia

AML-M3

Promyelocytic leukemia cell line responsive to differentiation-inducing agents. Classic model for evaluation of compounds inducing myeloid differentiation or apoptosis in hematologic malignancies.

K562

ATCC CCL-243

Chronic Myelogenous Leukemia

BCR-ABL+ CML Blast Crisis

BCR-ABL fusion-positive CML model in blast crisis. Relevant for evaluation of tyrosine kinase inhibitor activity and compounds targeting BCR-ABL-dependent signaling pathways.

Cell Line Authentication & Quality Control

All cell lines are obtained from ATCC or equivalent recognized repositories. Authentication by STR profiling is performed prior to experimental use. Regular mycoplasma testing is conducted throughout the experimental lifecycle to ensure culture integrity. Cell line passage numbers are tracked and maintained within validated ranges for each line.